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KMID : 0379119990270020175
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Korean Journal of Mycology
1999 Volume.27 No. 2 p.175 ~ p.179
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Antiviral Effect of Water soluble Substance from Elfvingia applanata Alone and in Combinations with Interferons Against Vesicular Stomatitis Virus (New Jersey Serotype)
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Abstract
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In order to find less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers.) Karst. Antiviral activity of EA against vesicular stomatitis virus [New Jersey serotype, VSV(NJ)] was examined in Vero cells using plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of VSV(NJ). EA caused a concentration-dependent reduction in the plaque formation of VSV(NJ) with 50% effective concentration (EC_(50)) of 2.10 ㎎/㎖. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed more potent effect with CI values of 0.87∼1.59 for 50%, 70% and 90% effective levels than that with INF gamma with CI values of 1.05∼2.03.
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